Increasing global incidence of central precocious puberty

Precocious puberty is a prevalent endocrine disorder that affects children globally. Classically, precocious puberty is defined as the development of secondary sexual characteristics before age 8 years in girls and 9 years in boys and it has a clear female predominance.

Noonan syndrome

Noonan syndrome is a relatively common autosomal dominant disorder characterised by facial dysmorphism, short stature, chest deformities and congenital heart defects.