News

The Guideline Development Group has created a set of UK guidelines to aid clinicians in the diagnosis and treatment of children and young people with adamantinomatous craniopharyngiomas.

Adolescents with a history of idiopathic central precocious puberty may be at increased risk of polycystic ovary syndrome, researchers report.

The incidence of type 1 diabetes among children under 15 years of age in Ireland, a high incidence country, is increasing again following a period of stabilisation, particularly among younger age groups, a nationwide study shows.

A study of children and young people with congenital adrenal hyperplasia in the UK shows poor quality of life in this patient population compared with healthy peers, with height and weight significant predictors of this outcome.

Two-year findings from the REAL4 trial support a switch from daily growth hormone to a weekly dose of the long-acting derivative somapacitan for prepubertal children with GH deficiency.

A study of children from Qatar with severe early-onset obesity suggests that around 15% of cases may be explained by rare genetic variants within the leptin–melanocortin pathway and other signalling pathways.

Multifocal disease does not predict a poor outcome in children and adolescents with papillary thyroid cancer, suggest study findings from the Memorial Sloan Kettering Cancer Center in New York, USA.

Research shows that growth hormone stimulation testing failure is more common in children with short stature or impaired linear growth who also have a diagnosis of attention deficit hyperactivity disorder.

A study of children in Finland reveals that diagnosis of primary adrenal insufficiency is most common shortly after birth and related to congenital adrenal hyperplasia, but after age 4 years, autoimmune-related diagnoses become more frequent.

Measuring morning salivary cortisol can be used to assess hypothalamic–pituitary–adrenal axis recovery in children who have completed a prolonged period of corticosteroid therapy, show study findings published in Hormone Research in Paediatrics.

The CRF1 receptor antagonist crinecerfont achieves “substantial reductions” in adrenal androgens and androgen precursors in adolescents with congenital adrenal hyperplasia due to 21-hydroxylase deficiency, US researchers say.

Women diagnosed with non-classical congenital adrenal hyperplasia during childhood or adolescence do not typically reach their target height, but this is not related to glucocorticoid treatment duration and dose, research shows.