Pituitary/growth disorders


Women diagnosed with non-classical congenital adrenal hyperplasia during childhood or adolescence do not typically reach their target height, but this is not related to glucocorticoid treatment duration and dose, research shows.
Genetic variations in genes regulating the growth plate appear to play a “central role” in the aetiology of persistent short stature among children born small for gestational age, report researchers from the Czech Republic.
Researchers have identified two naturally occurring, dominant-negative variants in the growth hormone receptor gene that act via the same molecular mechanism and contribute to the nonclassical growth hormone insensitivity phenotype.
Observational data confirm that children born small for gestational age achieve the best growth outcomes if they start treatment with recombinant human growth hormone as young as possible.

In depth

Professor Martin Savage discusses the roles of clinical, endocrinological and genetic testing in the diagnosis and care of children with idiopathic short stature.
WEBCAST NOW AVAILABLE This is the 9th IMAGE programme, which focuses on transgender management, bone health, and the genetics and treatment of growth disorders.
Why is the growth plate the most important organ for childhood growth: how can it be investigated for clinical diagnosis?
A 4-year-old girl is referred to the local paediatric endocrine unit with signs of pubertal development.
Martin Savage
Programme Director

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This programme is made possible thanks to an educational grant received from Merck Healthcare KGaA, Darmstadt, Germany.
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