The diagnosis of central congenital hypothyroidism with or without multiple pituitary hormone deficiencies is frequently missed in children, even among those admitted to hospital, say Dutch researchers.
While adrenal disease in children is quite rare, healthcare professionals today working in paediatric endocrinology departments are experts in managing the care of children with adrenal disease.
Hydrocortisone granules provide a straightforward and accurate means of treating infants and young children with congenital adrenal hyperplasia, with the largest issue being weaning them off sweetened pharmacy-compounded powder, research shows.
Primary ovarian insufficiency affects the majority of girls with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy, in most cases occurring before they have attained their final adult height, show data from a national cohort.
Congenital adrenal hyperplasia is a disorder of decreased cortisol production coupled with an increase in androgens from a compensatory adrenocorticotropic hormone drive.
Three-week-old baby referred to the paediatric endocrine clinic from a general paediatrician with ambiguous genitalia, accompanied by very anxious and upset parents.
Giving hydrocortisone four times daily at a time-varying dose may be the best approach for children with congenital adrenal hyperplasia, say the authors of a pharmaco-kinetic and pharmaco-dynamic modelling study.
Factors including age at diagnosis and the specific disease influence the likelihood of children with chronic endocrine conditions being lost to follow-up, show French study findings.
Our podcast with Dr Sogol Mostoufi, from the Children’s Hospital of Philadelphia in Pennsylvania, USA, focuses on the treatment-related endocrine side effects commonly experienced by childhood cancer survivors, and the need for screening, life-long follow-up and treatment in this high-risk population.
The European Cooperation in Science and Technology Action DSDnet group have published recommendations for standardised data collection during clinical follow-up of patients with differences of sexual development.
