Plasma concentrations of the adrenal-derived 11-oxygenated-C19 androgen 11-ketotestosterone strongly correlate with salivary levels in children with congenital adrenal hyperplasia, UK researchers report.
The risk of a false–positive result on a low-dose adrenocorticotropic hormone stimulation test can be reduced in children by measuring cortisol levels at three consecutive time points instead of just one, researchers say.
Researchers have defined urinary steroid metabolite levels that indicate inadequate and excessive adrenal suppression for children with congenital adrenal hyperplasia undergoing glucocorticoid treatment.
In our first edition, Professor Frederic Castinetti discussing the results of an international collaboration to study the natural history and treatment outcomes of multiple endocrine neoplasia type 2B, and Professor Martin Savage comments on a randomized trial of letrozole versus testosterone in boys with constitutional delay of growth and puberty.
Basal adrenal androgen levels can help identify girls with non-classical congenital adrenal hyperplasia who present as central precocious puberty, but adrenocorticotrophic hormone stimulation may be needed for a firm diagnosis, say researchers.
A multicentre collaborative study shows that early thyroidectomy offers a high chance of a cure for patients with multiple endocrine neoplasia type 2B, as long as it is performed before the age of 1 year.
The introduction of glucocorticoid replacement for congenital adrenal hyperplasia has revolutionised the outlook for patients with this lifelong condition, preventing life-threatening salt-wasting crises.
