The CRF1 receptor antagonist crinecerfont achieves “substantial reductions” in adrenal androgens and androgen precursors in adolescents with congenital adrenal hyperplasia due to 21-hydroxylase deficiency, US researchers say.
Children’s weight trajectories between birth and 4 years of age are associated with their dehydroepiandrosterone sulphate levels at age 7 years, study findings show.
Researchers recommend next-generation sequencing for the first-line diagnosis of patients with 46,XY differences of sex development.
Steroid hormone profiles can identify the majority of children with non-congenital adrenal hyperplasia primary adrenal insufficiency, say researchers.
In our latest podcast, Specialist nurse and educator Kate Davies asks clinical psychologist Julie Alderson about the optimal integration of psychology into a differences in sexual development clinical service.
A study of children and adolescents with classic 21-hydroxylase deficiency has found no significant difference in outcomes when giving the highest hydrocortisone dose of the thrice-daily schedule in the morning or the evening.
Programme Director Professor Martin Savage is joined by experts to present and discuss the application of precision medicine in endocrine disorders, offering clinical expertise and insight, evidence and opinion on this topic.
Research from New Zealand shows that the rate of false-positive neonatal screening tests for congenital adrenal hyperplasia can be reduced without a loss in sensitivity by assessing additional steroid markers adjusted for birthweight or corrected gestational age.
Many children with congenital adrenal hyperplasia may be receiving excessively high hydrocortisone doses, especially during the earliest months of life, a study suggests.
Researchers find that teenagers with endocrine disorders often have gaps in their knowledge of their condition and how to manage it, making them poorly prepared for transition to adult clinic.
