Measures of obesity are significantly associated with increased androgen production in children, even in the absence of physical signs of puberty, researchers report.
Researchers find that teenagers with endocrine disorders often have gaps in their knowledge of their condition and how to manage it, making them poorly prepared for transition to adult clinic.
Routine use of magnetic resonance imaging for girls with central precocious puberty is the best way to identify occult central nervous system lesions, say Turkish researchers.
Longitudinal study findings support a relationship between body mass index and the timing of puberty in boys, with a link found between obesity and precocious gonadarche.
Familial central precocious puberty caused by mutations in the makorin RING finger protein 3 gene is phenotypically similar to idiopathic forms, although it can vary with the severity of the mutation, a study shows.
Watch the webcast that was recorded in São Paolo with regional experts Dr Alexander Jorge and Professor Ana Claudia Latronico. We discussed the translational advances in Latin America and how an improved understanding of the genetics have contributed to the diagnostics and treatment of growth and puberty disorders.
The incidences of central precocious puberty and normal variant puberty have risen over the past 20 years, in line with overall population trends for earlier puberty in both girls and boys, say researchers.
Primary ovarian insufficiency affects the majority of girls with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy, in most cases occurring before they have attained their final adult height, show data from a national cohort.
Whole-gene deletion of MKRN3 can cause central precocious puberty without any features of Prader–Willi syndrome, researchers report.