The likelihood of finding an underlying genetic cause of short stature in children is markedly increased if they have additional factors such as dysmorphic facial features or skeletal dysplasia, say researchers.
The evaluation of children presenting with short stature includes detailed clinical, phenotypic, auxological and biochemical assessments with genetic analyses in selected cases.
Recombinant human growth hormone appears to have a positive effect on growth in children with Kabuki Syndrome, shows an open-label study.
Programme Director Professor Martin Savage is joined by experts to present and discuss the application of precision medicine in endocrine disorders, offering clinical expertise and insight, evidence and opinion on this topic.
Children with Cushing’s disease who have a negative magnetic resonance imaging pituitary scan are less likely to achieve remission after surgery than those with a confirmed tumour, say researchers.
A cohort study of healthy infants has characterised the relationships between circulating levels of insulin-like growth factor-I and insulin-like growth factor binding protein-3 and changes in body length and weight in the first year of life.
A phase 2 study of macimorelin in children with suspected growth hormone deficiency shows similar results to those established in adults.
The human leukocyte antigen polymorphisms that increase the risk of type 1 diabetes are linked to growth and insulin-like growth factor-I levels during infancy, say researchers.
The heiGHt Trial investigators report that once-weekly treatment with lonapegsomatropin offers noninferior and indeed superior annualised height velocity to that achieved with daily somatropin for children with growth hormone deficiency.
Findings from the PATRO Children study support the use of a biosimilar formulation of recombinant human growth hormone (somatropin) in children with Turner’s syndrome.
