Androgen increases may compensate for low birthweight in infant boys
September 5, 2022
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A study of preterm boys shows increased androgen levels at the estimated time of birth in those with low birthweight.
Topic: Growth disorders
UK auxological referral criteria have low sensitivity for pathological short stature
August 1, 2022
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Using both height and deviation from height target during growth monitoring could improve detection of pathological growth disorders in children and avoid unnecessary clinic referrals, suggest UK researchers who found the current criteria to have low sensitivity.
GHD reversal common, dependent on GH cutoff in diagnostic stimulation test
July 4, 2022
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A systematic review and meta-analysis confirms a high rate of reversal of idiopathic growth hormone deficiency, albeit strongly dependent on the peak GH cutoff used.
Weekly somatrogon noninferior to daily somatropin in paediatric GHD
May 3, 2022
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Weekly injections of somatrogon result in similar height gains to daily somatropin treatment in children with growth hormone deficiency, show results of a 12-month phase 3 trial.
Increased peak GH response with oral GH secretagogue receptor agonist in children with GHD
May 3, 2022
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An oral growth hormone secretagogue receptor agonist produces larger GH responses than standard stimulation tests in children with growth hormone deficiency, study findings suggest.
rhGH therapy boosts adult height among children with SHOX haploinsufficiency
May 3, 2022
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A study of Brazilian children with isolated SHOX haploinsufficency who were followed up until adult height has demonstrated a long-term benefit of recombinant human growth hormone therapy with or without puberty modulator treatment.
Management of Silver–Russell Syndrome
April 25, 2022
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A 4-year-old girl is referred to the local paediatric endocrine unit with signs of pubertal development.
Switch from daily to weekly rhGH feasible and popular for children with GHD
April 4, 2022
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Children with growth hormone deficiency maintain their growth trajectories if they switch from a daily recombinant human growth hormone to weekly lonapegsomatropin, and the vast majority prefer the less frequent injections, show the results of the fliGHt trial.
Silver-Russell syndrome patients derive lasting height and BMI benefits from rhGH treatment
April 4, 2022
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Treatment with recombinant human growth hormone results in an increased final adult height in children with molecularly confirmed Silver–Russell syndrome, as well as an improved BMI that persists after treatment cessation, say researchers.
Growth hormone benefit in Noonan syndrome demonstrated regardless of PTPN11 mutation status
April 4, 2022
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The benefit of initiating recombinant human growth hormone before puberty in patients with Noonan syndrome occurs regardless of whether the children carry a PTPN11 mutation, suggests research published in Endocrine Connections.
