Glucose–insulin impairment in small-for-gestational-age children is comparable to that found in children with obesity and worsened by use of growth hormone therapy, say German researchers.
Use of the glucagon-like peptide -1 receptor agonist liraglutide alongside diet and exercise guidance significantly reduces BMI in children aged 6 to 11 years with severe obesity compared with lifestyle interventions alone, shows the SCALE Kids Trial.
Phase 2 trial results support use of the melanocortin-4 receptor agonist setmelanotide for the treatment of rapid excess weight gain and hunger in patients with hypothalamic obesity.
The optimal exercise for improving insulin resistance in children and adolescents with overweight is a minimum of two to three 60-minute sessions per week of high-intensity interval training with or without resistance training, suggests a systematic review and extensive network meta-analysis.
A weekly injection of a high dose of semaglutide results in substantial weight loss among adolescents with obesity, show the STEP TEENS trial findings.
A small number of clinical predictors and blood metabolites at birth may accurately predict which infants will have a BMI trajectory leading to overweight or obesity, a study suggests.
Children’s weight trajectories between birth and 4 years of age are associated with their dehydroepiandrosterone sulphate levels at age 7 years, study findings show.
In our latest podcast, Professor Sadaf Farooqi discusses the most recent findings from the Genetics Of Obesity Study, and what they mean for families and children with severe early-onset obesity.
Researchers have identified pathogenic mutations in the gene encoding the stimulatory G-protein alpha subunit protein in children with severe obesity but few or no clinical signs of pseudohypoparathyroidism.
Programme Director Professor Martin Savage is joined by experts to present and discuss the application of precision medicine in endocrine disorders, offering clinical expertise and insight, evidence and opinion on this topic.
