ADHD linked to growth hormone stimulation testing failure in children with short stature
Research shows that growth hormone stimulation testing failure is more common in children with short stature or impaired linear growth who also have a diagnosis of attention deficit hyperactivity disorder.
Childhood primary adrenal insufficiency diagnosis pattern changes with age
A study of children in Finland reveals that diagnosis of primary adrenal insufficiency is most common shortly after birth and related to congenital adrenal hyperplasia, but after age 4 years, autoimmune-related diagnoses become more frequent.
Morning saliva points to paediatric HPA axis recovery after corticosteroid therapy
Measuring morning salivary cortisol can be used to assess hypothalamic–pituitary–adrenal axis recovery in children who have completed a prolonged period of corticosteroid therapy, show study findings published in Hormone Research in Paediatrics.
Crinecerfont combats androgen excess in adolescents with congenital adrenal hyperplasia
The CRF1 receptor antagonist crinecerfont achieves “substantial reductions” in adrenal androgens and androgen precursors in adolescents with congenital adrenal hyperplasia due to 21-hydroxylase deficiency, US researchers say.
Glucocorticoid treatment does not impact adult height in girls with NCCAH
Women diagnosed with non-classical congenital adrenal hyperplasia during childhood or adolescence do not typically reach their target height, but this is not related to glucocorticoid treatment duration and dose, research shows.
New light shed on genetic landscape of SGA children who remain short
Genetic variations in genes regulating the growth plate appear to play a “central role” in the aetiology of persistent short stature among children born small for gestational age, report researchers from the Czech Republic.
Novel GHR variants may hold clues to treatment targets for short stature
Researchers have identified two naturally occurring, dominant-negative variants in the growth hormone receptor gene that act via the same molecular mechanism and contribute to the nonclassical growth hormone insensitivity phenotype.
Suicidality common hospitalisation cause for gender-variant young people
Suicidality or self-harm is a frequent cause of hospital admission among gender variant/diverse young people, report researchers.
Real-world data support early rhGH initiation for SGA children
Observational data confirm that children born small for gestational age achieve the best growth outcomes if they start treatment with recombinant human growth hormone as young as possible.
High-dose semaglutide triggers weight loss in adolescents with obesity
A weekly injection of a high dose of semaglutide results in substantial weight loss among adolescents with obesity, show the STEP TEENS trial findings.
