‘Highly variable’ PHP Type IA clinical presentation and natural history highlighted
A diagnosis of pseudohypoparathyroidism type IA should be considered for infants who present with a combination of congenital hypothyroidism, parathyroid hormone resistance, early-onset obesity or minor dysmorphic features, Israeli clinicians suggest.
GnRHa therapy poses no BMD risk for children with CAH
Gonadotropin-releasing hormone agonist therapy in children with congenital adrenal hyperplasia does not compromise bone mineral density, US researchers say.
Machine learning analysis may differentiate idiopathic CPP from nonprogressive premature thelarche
Applying a machine learning technique to hormone measurements can help determine whether a girl with early signs of puberty has nonprogressive premature thelarche or may require treatment for idiopathic central precocious puberty, suggest study findings published in The Journal of Clinical Endocrinology & Metabolism.
UK issues national guidelines for paediatric craniopharyngioma management
The Guideline Development Group has created a set of UK guidelines to aid clinicians in the diagnosis and treatment of children and young people with adamantinomatous craniopharyngiomas.
PCOS prevalence increased in adolescents with idiopathic central precocious puberty
Adolescents with a history of idiopathic central precocious puberty may be at increased risk of polycystic ovary syndrome, researchers report.
Incidence of childhood type 1 diabetes on the rise in Ireland
The incidence of type 1 diabetes among children under 15 years of age in Ireland, a high incidence country, is increasing again following a period of stabilisation, particularly among younger age groups, a nationwide study shows.
Childhood congenital adrenal hyperplasia QoL affected by height and weight
A study of children and young people with congenital adrenal hyperplasia in the UK shows poor quality of life in this patient population compared with healthy peers, with height and weight significant predictors of this outcome.
REAL4 results support switch from daily to weekly long-acting growth hormone treatment
Two-year findings from the REAL4 trial support a switch from daily growth hormone to a weekly dose of the long-acting derivative somapacitan for prepubertal children with GH deficiency.
Qatar study points to monogenic aetiology in 15% of early-onset childhood obesity cases
A study of children from Qatar with severe early-onset obesity suggests that around 15% of cases may be explained by rare genetic variants within the leptin–melanocortin pathway and other signalling pathways.
Multifocality does not predict childhood and adolescent papillary thyroid cancer outcome
Multifocal disease does not predict a poor outcome in children and adolescents with papillary thyroid cancer, suggest study findings from the Memorial Sloan Kettering Cancer Center in New York, USA.
