Exercise improves insulin resistance markers in youths with overweight
The optimal exercise for improving insulin resistance in children and adolescents with overweight is a minimum of two to three 60-minute sessions per week of high-intensity interval training with or without resistance training, suggests a systematic review and extensive network meta-analysis.
Adrenal insufficiency common in children with single large-scale mitochondrial DNA deletions
Adrenal insufficiency is a common clinical feature in children and young adults with single large-scale mitochondrial DNA deletions, especially in those with Pearson syndrome, Italian researchers have found.
Paediatric ectopic ACTH syndrome aetiology differs to that of adults
Children and adolescents with ectopic adrenocorticotropic hormone syndrome show a different aetiological profile to that of adults, suggests a systematic review of the literature.
Exome sequencing may aid short stature investigation where genetic syndrome is suspected
Exome sequencing and chromosomal microarray analysis are useful tools for the identification of genetic causes underlying short stature, indicate the results of a systematic review and meta-analysis.
‘Highly variable’ PHP Type IA clinical presentation and natural history highlighted
A diagnosis of pseudohypoparathyroidism type IA should be considered for infants who present with a combination of congenital hypothyroidism, parathyroid hormone resistance, early-onset obesity or minor dysmorphic features, Israeli clinicians suggest.
GnRHa therapy poses no BMD risk for children with CAH
Gonadotropin-releasing hormone agonist therapy in children with congenital adrenal hyperplasia does not compromise bone mineral density, US researchers say.
Machine learning analysis may differentiate idiopathic CPP from nonprogressive premature thelarche
Applying a machine learning technique to hormone measurements can help determine whether a girl with early signs of puberty has nonprogressive premature thelarche or may require treatment for idiopathic central precocious puberty, suggest study findings published in The Journal of Clinical Endocrinology & Metabolism.
UK issues national guidelines for paediatric craniopharyngioma management
The Guideline Development Group has created a set of UK guidelines to aid clinicians in the diagnosis and treatment of children and young people with adamantinomatous craniopharyngiomas.
PCOS prevalence increased in adolescents with idiopathic central precocious puberty
Adolescents with a history of idiopathic central precocious puberty may be at increased risk of polycystic ovary syndrome, researchers report.
Incidence of childhood type 1 diabetes on the rise in Ireland
The incidence of type 1 diabetes among children under 15 years of age in Ireland, a high incidence country, is increasing again following a period of stabilisation, particularly among younger age groups, a nationwide study shows.