Type 1/monogenic diabetes
NEWS
Researchers have characterised the pathogenesis, prognosis, treatment, neurological sequelae and prevalence of congenital hyperinsulinism in children born in Norway, finding genetic alterations to ABCC8 to be the most common cause of the condition.
A study of children from Qatar with severe early-onset obesity suggests that around 15% of cases may be explained by rare genetic variants within the leptin–melanocortin pathway and other signalling pathways.
Neurodevelopmental disorders are frequent and diverse in children with hyperinsulinism/hyperammonaemia syndrome caused by a GLUD1 mutation, a study shows.
Children with islet autoantibodies are highly likely to progress to clinical diabetes within the next year if their glucose levels are hyperglycaemic for more than 10% of the time, show findings from the ASK study.
In depth
Programme Director Professor Martin Savage is joined by experts to present and discuss the application of precision medicine in endocrine disorders, offering clinical expertise and insight, evidence and opinion on this topic.
