The TRANSECEND trial confirms that the melanocortin-4 receptor agonist setmelanotide achieves a significantly greater reduction in BMI and hunger than placebo in children, adolescents and adults with acquired hypothalamic obesity.
The optimal exercise for improving insulin resistance in children and adolescents with overweight is a minimum of two to three 60-minute sessions per week of high-intensity interval training with or without resistance training, suggests a systematic review and extensive network meta-analysis.
The incidence of type 1 diabetes among children under 15 years of age in Ireland, a high incidence country, is increasing again following a period of stabilisation, particularly among younger age groups, a nationwide study shows.
Children’s weight trajectories between birth and 4 years of age are associated with their dehydroepiandrosterone sulphate levels at age 7 years, study findings show.
Researchers have identified pathogenic mutations in the gene encoding the stimulatory G-protein alpha subunit protein in children with severe obesity but few or no clinical signs of pseudohypoparathyroidism.
Programme Director Professor Martin Savage is joined by experts to present and discuss the application of precision medicine in endocrine disorders, offering clinical expertise and insight, evidence and opinion on this topic.
Researchers describe a novel autosomal recessive genetic syndrome that may be misdiagnosed as Prader–Willi syndrome.
Overweight and obese boys have reduced testosterone levels and shorter penises during puberty than their normal-weight counterparts, study findings demonstrate in The Journal of Clinical Endocrinology & Metabolism.
Children with monogenic obesity linked to mutations in the leptin-melanocortin pathway have lower cardiac muscle mass than other obese children, as well as greater tissue storage of sodium, research suggests.
The melanocortin 4 receptor agonist setmelanotide has significantly reduced hunger and resulted in weight loss in a phase 3 trial involving patients, including children, with pro-opiomelanocortin or leptin receptor deficiency obesity.
