Researchers have characterised the pathogenesis, prognosis, treatment, neurological sequelae and prevalence of congenital hyperinsulinism in children born in Norway, finding genetic alterations to ABCC8 to be the most common cause of the condition.
A study of children from Qatar with severe early-onset obesity suggests that around 15% of cases may be explained by rare genetic variants within the leptin–melanocortin pathway and other signalling pathways.
Neurodevelopmental disorders are frequent and diverse in children with hyperinsulinism/hyperammonaemia syndrome caused by a GLUD1 mutation, a study shows.
Children with islet autoantibodies are highly likely to progress to clinical diabetes within the next year if their glucose levels are hyperglycaemic for more than 10% of the time, show findings from the ASK study.
Programme Director Professor Martin Savage is joined by experts to present and discuss the application of precision medicine in endocrine disorders, offering clinical expertise and insight, evidence and opinion on this topic.
Faster diagnosis and use of individualised treatments for congenital hyperinsulinism has led to major improvements in neurological and endocrine outcomes over time, say Finnish researchers.
Researchers have identified probable type 1 diabetes in children of an age more commonly associated with diagnosis of monogenic diabetes, raising the possibility that polygenic disease processes can begin in utero.
UK researchers have identified an increase in the number of childhood cases of new-onset type 1 diabetes during the COVID-19 pandemic, raising the possibility of a link with SARS-CoV-2 infection.
A major analysis covering three continents suggests that diabetic ketoacidosis remains unacceptably common among children newly identified with type 1 diabetes and shows few signs of improving.
Factors including age at diagnosis and the specific disease influence the likelihood of children with chronic endocrine conditions being lost to follow-up, show French study findings.
