Brain imaging ‘provides valuable information’ in girls with central precocious puberty
More than half of girls with central precocious puberty have abnormal findings on magnetic resonance imaging of the brain, report researchers.
Model predicts infant BMI trajectory to obesity
A small number of clinical predictors and blood metabolites at birth may accurately predict which infants will have a BMI trajectory leading to overweight or obesity, a study suggests.
Androgen increases may compensate for low birthweight in infant boys
A study of preterm boys shows increased androgen levels at the estimated time of birth in those with low birthweight.
Young people largely remain committed to endocrine transgender treatment
Most young people treated within a paediatric gender identity development service remain committed to pursuing hormonal treatment in line with their perceived gender, research shows.
Most young transgender people continue to identify as gender variant into adulthood
Most children and adolescents who identify as transgender or gender variant continue with hormone interventions after discharge from youth endocrine services, a study shows.
UK auxological referral criteria have low sensitivity for pathological short stature
Using both height and deviation from height target during growth monitoring could improve detection of pathological growth disorders in children and avoid unnecessary clinic referrals, suggest UK researchers who found the current criteria to have low sensitivity.
Combined pituitary hormone deficiency diagnosis often delayed
Childhood-onset combined pituitary hormone deficiency occurs in around one in 16,000 children, but its diagnosis is often delayed due to nonspecific presenting symptoms, say researchers.
Minipuberty in females is ‘biphasic and prolonged’
Researchers report a “biphasic and prolonged” minipuberty in girls, and provide reference ranges for reproductive hormones during the first year of life.
Genotype may influence bisphosphonate response in osteogenesis imperfecta
Non-autosomal dominant inheritance and the presence of structural collagen defects are associated with reduced benefit of treatment with zoledronic acid in children with osteogenesis imperfecta, researchers report.
GHD reversal common, dependent on GH cutoff in diagnostic stimulation test
A systematic review and meta-analysis confirms a high rate of reversal of idiopathic growth hormone deficiency, albeit strongly dependent on the peak GH cutoff used.
