Translational advances in the management of growth and puberty disorders

Recorded in São Paolo, Brazil

Watch the webcast that was recorded in São Paolo with regional experts Dr Alexander Jorge and Professor Ana Claudia Latronico. We discussed the translational advances in Latin America and how an improved understanding of the genetics have contributed to the diagnostics and treatment of growth and puberty disorders.

This programme is in affiliation with

Chaired by Professor Martin Savage, this interactive independent medical education webcast focuses on managing growth and puberty disorders, specifically in a Latin American setting.  Our panel of international experts presented and discussed the role of genetic contributions in paediatric endocrine disorders, growth disorders, abnormal puberty, short stature and central precocious puberty.

Topics Speaker
Introduction Martin Savage
Advances in the genetic diagnosis of paediatric endocrine disorders Alexander Jorge
Investigation of growth disorders: genetic contributions Alexander Jorge
Investigation of abnormal puberty: genetic contributions Ana Claudia Latronico
Therapy of short stature: genetic influences Alexander Jorge
Management of central precocious puberty Ana Claudia Latronico
Summary Martin Savage
Discussion and Q & A All

This webcast is suitable for, but not limited to, clinical paediatric endocrinologists, clinical adult endocrinologists, paediatric endocrine nurses, and all other healthcare professionals interested in the management of growth disorders.

Following this webcast you will be able to:

  1. Explain the recent genetic advances in growth and puberty disorders
  2. Explore how genetic advances can influence and improve the diagnostic and management approach to growth and puberty disorders
  3. Interpret the clinical presentation of central precocious puberty to determine the best therapeutic approach

Emeritus Professor of Paediatric Endocrinology

William Harvey Research Institute, Barts and the London School of Medicine & Dentistry, London, UK

Martin Savage is Emeritus Professor of Paediatric Endocrinology at William Harvey Research Institute, Barts and the London School of Medicine & Dentistry in London. He was head of the Paediatric Endocrine Unit at Barts and the London School of Medicine from 1982 to 2007. He is a clinician with clinical and research interests in growth disorders, specifically those with abnormalities in the growth hormone-IGF-1 axis. His main research field has been the phenotype:genotype relationships of GH-IGF-1 axis defects. He published the first human case of an IGF-1 gene defect in the New England Journal of Medicine in 1996.

His other clinical interests are Cushing’s syndrome and growth in chronic inflammatory diseases. He was General Secretary of the European Society for Paediatric Endocrinology (ESPE) from 1997 to 2004. Professor Savage has lectured in 59 countries world-wide and has published over 440 original articles, reviews, textbook chapters and books. In 2007, he was awarded the ESPE Andrea Prader Prize for contributions to paediatric endocrinology and in 2018 he received a Visionary Award from the American Human Growth Foundation. He continues to lecture nationally and internationally.

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Associate Professor of Medicine

University of São Paulo School of Medicine, Brazil

Alexander Jorge is Associate Professor of Medicine at The University of São Paulo (USP), School of Medicine. He is a clinical endocrinologist as well as a translational researcher. Dr Jorge is a principal investigator at the Developmental Endocrinology Unit and Genetic Endocrinology Unit. He is an expert in growth disorders and has published more than 100 papers in various international scientific journals. He is responsible for molecular genetic investigation of several endocrine genetic disorders at the largest hospital in South America (Hospital das Clínicas de São Paulo). His research is centered on discovering and understanding the genetic mechanisms involved in monogenic endocrine diseases, in particular those associated with growth and development disorders.

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Professor of Medicine

University of São Paolo, Brazil This image has an empty alt attribute; its file name is Fotos-ACL-Ampliadas-904x1024.jpg

Ana Latronico is Professor of Medicine (Department of Internal Medicine, Endocrinology and Metabology) at the School of Medicine, University of São Paulo (USP). She is also Head of the Endocrinology and Metabology Service, Hospital das Clínicas; Deputy Coordinator of the Graduate Program in Endocrinology at FMUSP, and Principal Researcher at the Laboratory of Hormones and Molecular Genetics LIM / 42 at USP Clinical Hospital. Prof Latronico is a full member of the Brazilian Academy of Sciences.

Prof Latronico graduated in medicine at Faculty of Medical Sciences of Santos, Lusíada Foundation in 1987. She was Resident Physician at the Department of Medical Clinic / Endocrinology, Hospital das Clínicas (1988-1991), became a Specialist in Endocrinology and Metabology and then in Pediatric Endocrinology. She gained her PhD in Endocrinology from the Faculty of Medicine of the University of São Paulo in 1995.

In 2003 Prof Latronico won the Richard E. Weitzman Memorial Award (2003) and has since gone on to be the recipient of many distinguished awards. She is author of more than 170 original manuscripts published in international and national journals, including 4 in the New England Journal of Medicine. Her main research focus is clinical and molecular aspects of precocious puberty, hypogonadotropic hypogonadism and adrenocortical tumors.

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This programme is made possible thanks to an educational grant received from: Merck Healthcare KGaA, Darmstadt, Germany

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