Cardiological tests indicated in melanocortin pathway mutations linked to reduced cardiac mass
Children with monogenic obesity linked to mutations in the leptin-melanocortin pathway have lower cardiac muscle mass than other obese children, as well as greater tissue storage of sodium, research suggests.
Scoliosis risk in PWS independent of growth hormone treatment
A long-term follow-up study of children with Prader-Willi syndrome has found no evidence to indicate that growth hormone therapy affects the risk or severity of scoliosis in this population.
Scoliosis risk in PWS independent of growth hormone treatment
A long-term follow-up study of children with Prader-Willi syndrome has found no evidence to indicate that growth hormone therapy affects the risk or severity of scoliosis in this population.
Bodyweight link to androgen production in prepubertal children confirmed
Measures of obesity are significantly associated with increased androgen production in children, even in the absence of physical signs of puberty, researchers report.
Hydrocortisone overdosing remains common in children with CAH
Many children with congenital adrenal hyperplasia may be receiving excessively high hydrocortisone doses, especially during the earliest months of life, a study suggests.
Knowledge gaps make teens with endocrine disorders unready for transition to adult clinic
Researchers find that teenagers with endocrine disorders often have gaps in their knowledge of their condition and how to manage it, making them poorly prepared for transition to adult clinic.
Polygenic risk score rivals mid-parental height for predicting adult short stature
A polygenic risk score for height can predict a child’s adult height with similar accuracy to their mid-parental height, say researchers.
MRI screening ‘most efficient approach’ for CNS lesions in girls with central precocious puberty
Routine use of magnetic resonance imaging for girls with central precocious puberty is the best way to identify occult central nervous system lesions, say Turkish researchers.
Endocrinopathy risk highlighted among childhood brain tumour survivors
Around 70% of children who survive a brain tumour develop at least one form of endocrine dysfunction, suggests a long-term study of patients attending a hospital in Portugal.
Increased cardiometabolic risk appears from childhood in CAH patients
Children with congenital adrenal hyperplasia have an increased propensity to develop cardiometabolic risk factors in childhood, research shows.
Favourable outcomes possible for autosomal recessive pseudohypoaldosteronism type 1
Researchers report that good outcomes are possible for children with autosomal recessive pseudohypoaldosteronism type 1, despite its high morbidity and mortality risk.
Treatment advances translate to better congenital hyperinsulinism outcomes
Faster diagnosis and use of individualised treatments for congenital hyperinsulinism has led to major improvements in neurological and endocrine outcomes over time, say Finnish researchers.