50-year study of boys illustrates long-term trend towards earlier puberty
A Swedish study suggests that, as with girls, puberty has shifted to begin at an earlier age in boys.
C-type natriuretic peptide analogue increases growth velocity in children with achondroplasia
Daily treatment with subcutaneous vosoritide leads to a sustained increase in annualised growth velocity, with generally mild side effects, in children with achondroplasia, show data published in The New England Journal of Medicine.
Day One: Sleep quality must be taken seriously
A plenary session at the 58th Annual ESPE Meeting in Vienna, Austria, has highlighted how wide-ranging the risks associated with sleep and circadian rhythm disruption are.
Salivary 11-ketotestosterone measurement could improve CAH management and outcomes
Plasma concentrations of the adrenal-derived 11-oxygenated-C19 androgen 11-ketotestosterone strongly correlate with salivary levels in children with congenital adrenal hyperplasia, UK researchers report.
Peripheral thyrotoxicosis due to MCT8 deficiency relieved with thyroid hormone analogue therapy
A once-daily regimen of the thyroid hormone analogue Triac normalised serum levels of tri-iodothyronine in a phase II trial of paediatric and adult patients with transporter monocarboxylate transporter 8 deficiency.
One in five childhood cancer survivors experience growth hormone deficiency
Growth hormone deficiency is common among childhood cancer survivors and is associated with the use of hypothalamic-pituitary radiotherapy, alkylating agents and intrathecal chemotherapy, as well as adverse health outcomes, say researchers.
Mixed picture in comprehensive study of European paediatric obesity trends
The prevalence of overweight and obesity remains high among European children, say researchers, with “worrisome” rising trends in some countries, despite stabilising rates and downwards trends in other countries.
50-year study of boys illustrates long-term trend towards earlier puberty
A Swedish study suggests that, as with girls, puberty has shifted to begin at an earlier age in boys.
Growth hormone prescription differences highlighted for USA vs Europe
Data from two large observational studies show that children treated in the USA receive a higher dose of the commercial growth hormone somatropin and are taller, older, and more likely to be boys than girls relative to those treated in Europe.
Glucose levels in children with type 1 diabetes most variable before puberty
Prepubertal children with type 1 diabetes have greater variability in their blood glucose levels than older children, research suggests.
C-type natriuretic peptide analogue increases growth velocity in children with achondroplasia
Daily treatment with subcutaneous vosoritide leads to a sustained increase in annualised growth velocity, with generally mild side effects, in children with achondroplasia, show data published in The New England Journal of Medicine.
TODAY2 shows rapid progression of youth-onset type 2 diabetes
The latest TODAY2 findings show rapid accumulation of cardiovascular risk factors and diabetes complications following a diagnosis of type 2 diabetes during childhood or adolescence.
