Neonatal screening required for prompt central congenital hypothyroidism detection
The diagnosis of central congenital hypothyroidism with or without multiple pituitary hormone deficiencies is frequently missed in children, even among those admitted to hospital, say Dutch researchers.
Vosoritide ‘effective’ for increasing growth in children with achondroplasia
The C-type natriuretic peptide analogue vosoritide significantly increases the growth rate of children with achondroplasia, indicate the results of a randomised, double-blind phase 3 study published in The Lancet.
Rates of CPP and normal variant puberty on the rise
The incidences of central precocious puberty and normal variant puberty have risen over the past 20 years, in line with overall population trends for earlier puberty in both girls and boys, say researchers.
Diabetes with typical type 1 features can occur before the age of 6 months
Researchers have identified probable type 1 diabetes in children of an age more commonly associated with diagnosis of monogenic diabetes, raising the possibility that polygenic disease processes can begin in utero.
Bone growth biomarker may provide growth velocity snapshot
A single measurement of plasma levels of a fragment of type X collagen may give an instant picture of how fast a child is growing, say researchers.
Neonatal screening required for prompt central congenital hypothyroidism detection
The diagnosis of central congenital hypothyroidism with or without multiple pituitary hormone deficiencies is frequently missed in children, even among those admitted to hospital, say Dutch researchers.
Alternative anti-thyroid drug regimens equivalent for paediatric thyrotoxicosis in randomised trial
A randomised trial of children receiving treatment for thyrotoxicosis shows no difference in biochemical stability between block-and-replace and dose-titration strategies.
Copy number variants enriched among GH-, IGF-1-insensitive patients
Rare copy number variants have been identified in a study of children who have growth hormone insensitivity or insulin-like growth factor-1 insensitivity, shedding light on the genetic basis of their conditions.
Hydrocortisone granules allow precise low doses for paediatric CAH in clinical practice
Hydrocortisone granules provide a straightforward and accurate means of treating infants and young children with congenital adrenal hyperplasia, with the largest issue being weaning them off sweetened pharmacy-compounded powder, research shows.
Vosoritide ‘effective’ for increasing growth in children with achondroplasia
The C-type natriuretic peptide analogue vosoritide significantly increases the growth rate of children with achondroplasia, indicate the results of a randomised, double-blind phase 3 study published in The Lancet.
Type and site of radiotherapy may impact future response to GH therapy in cancer survivors
Children who receive total body irradiation or craniospinal radiation for cancer may have a reduced response to growth hormone therapy if they later require it, say researchers.
COVID-19 pandemic linked to increased incidence of new-onset childhood type 1 diabetes
UK researchers have identified an increase in the number of childhood cases of new-onset type 1 diabetes during the COVID-19 pandemic, raising the possibility of a link with SARS-CoV-2 infection.