Type 1 diabetes risk alleles linked to late-infancy growth
The human leukocyte antigen polymorphisms that increase the risk of type 1 diabetes are linked to growth and insulin-like growth factor-I levels during infancy, say researchers.
Cardiological tests indicated in melanocortin pathway mutations linked to reduced cardiac mass
Children with monogenic obesity linked to mutations in the leptin-melanocortin pathway have lower cardiac muscle mass than other obese children, as well as greater tissue storage of sodium, research suggests.
Type 1 diabetes risk alleles linked to late-infancy growth
The human leukocyte antigen polymorphisms that increase the risk of type 1 diabetes are linked to growth and insulin-like growth factor-I levels during infancy, say researchers.
Long-acting growth hormone prodrug ‘superior’ to daily somatropin
The heiGHt Trial investigators report that once-weekly treatment with lonapegsomatropin offers noninferior and indeed superior annualised height velocity to that achieved with daily somatropin for children with growth hormone deficiency.
Childhood obesity linked to decreased penile length in puberty
Overweight and obese boys have reduced testosterone levels and shorter penises during puberty than their normal-weight counterparts, study findings demonstrate in The Journal of Clinical Endocrinology & Metabolism.
rhGH biosimilar ‘effective’ for Turner’s syndrome height gain in clinical practice
Findings from the PATRO Children study support the use of a biosimilar formulation of recombinant human growth hormone in children with Turner’s syndrome.
Cardiological tests indicated in melanocortin pathway mutations linked to reduced cardiac mass
Children with monogenic obesity linked to mutations in the leptin-melanocortin pathway have lower cardiac muscle mass than other obese children, as well as greater tissue storage of sodium, research suggests.
Updated congenital adrenal hyperplasia strategy reduces false-positive screening rate
Research from New Zealand shows that the rate of false-positive neonatal screening tests for congenital adrenal hyperplasia can be reduced without a loss in sensitivity by assessing additional steroid markers adjusted for birthweight or corrected gestational age.
Growth hormone insensitivity encompasses wide range of clinical entities
Researchers have found a large variety of genetic diagnoses in children with short stature investigated for suspected growth hormone insensitivity.
Scoliosis risk in PWS independent of growth hormone treatment
A long-term follow-up study of children with Prader-Willi syndrome has found no evidence to indicate that growth hormone therapy affects the risk or severity of scoliosis in this population.
Bodyweight link to androgen production in prepubertal children confirmed
Measures of obesity are significantly associated with increased androgen production in children, even in the absence of physical signs of puberty, researchers report.
Hydrocortisone overdosing remains common in children with CAH
Many children with congenital adrenal hyperplasia may be receiving excessively high hydrocortisone doses, especially during the earliest months of life, a study suggests.