A once-daily regimen of the thyroid hormone analogue Triac normalised serum levels of tri-iodothyronine in a phase II trial of paediatric and adult patients with transporter monocarboxylate transporter 8 deficiency.
medwireNews goes behind the headlines, talking to researchers and independent experts about how the latest findings will impact clinicians caring for children with endocrine disorders.
In our first edition, Professor Frederic Castinetti discussing the results of an international collaboration to study the natural history and treatment outcomes of multiple endocrine neoplasia type 2B, and Professor Martin Savage comments on a randomized trial of letrozole versus testosterone in boys with constitutional delay of growth and puberty.
A multicentre collaborative study shows that early thyroidectomy offers a high chance of a cure for patients with multiple endocrine neoplasia type 2B, as long as it is performed before the age of 1 year.
Tongue lesions, gastrointestinal problems and musculoskeletal complaints are the most common symptoms for which children are investigated in the years leading up to a multiple endocrine neoplasia type 2B diagnosis, say researchers.
Established genetic risk factors for adult-onset Graves’ disease apply equally in patients with a diagnosis in childhood, say researchers.
Skewed inactivation of the X chromosome may underlie a proportion of cases of autoimmune thyroid disease in girls, research suggests.
Comorbidities account for increased mortality rate in children with central congenital hypothyroidism
The mortality rate in children with screen-detected congenital central hypothyroidism is elevated, but as the result of comorbidities rather than the condition itself, study findings show.
Repurposed insulin pump for PTH infusion an option for treatment-resistant paediatric hypoparathyroidism
Using an insulin pump to provide subcutaneous parathyroid hormone is an option for children with hypoparathyroidism and intestinal malabsorption, report researchers.
Children younger than 12 years should be carefully monitored after undergoing surgery for differentiated thyroid carcinoma because of a high risk of residual or recurrent disease, study results indicate.