Pubertal boys with true gynaecomastia have a significantly higher oestradiol-to-testosterone ratio than those with pseudogynaecomastia or healthy controls, observational study data show.
Factors including age at diagnosis and the specific disease influence the likelihood of children with chronic endocrine conditions being lost to follow-up, show French study findings.
Childhood cancer survivors and endocrinopathies – the need for oncologist and endocrinologist collaboration
Dr Sogol Mostoufi focuses on the treatment-related endocrine side effects commonly experienced by childhood cancer survivors, and the need for screening, life-long follow-up and treatment in this high-risk population.
Real-world data support guideline stance on rhGH plus GnRHa in central precocious or early and fast puberty
Girls with central precocious puberty or early and fast puberty benefit from the addition of recombinant human growth hormone to gonadotropin-releasing hormone analogues but the combination should not be routinely recommended, researchers report.
The European Cooperation in Science and Technology Action DSDnet group have published recommendations for standardised data collection during clinical follow-up of patients with differences of sexual development.
A Swedish study suggests that, as with girls, puberty has shifted to begin at an earlier age in boys.
medwireNews goes behind the headlines, talking to researchers and independent experts about how the latest findings will impact clinicians caring for children with endocrine disorders.
In our first edition, Professor Frederic Castinetti discussing the results of an international collaboration to study the natural history and treatment outcomes of multiple endocrine neoplasia type 2B, and Professor Martin Savage comments on a randomized trial of letrozole versus testosterone in boys with constitutional delay of growth and puberty.
Boys with constitutional delay of growth and puberty achieve greater testicular growth during 6 months of treatment with letrozole than with low-dose testosterone, show the findings of a randomised trial.
The research to date suggests that hormonal treatments achieve the intended physical results in transgender adolescents, but the evidence quality is low and psychosocial issues are barely addressed, say the authors of a systematic review.