Genetic testing can contribute to clinical diagnosis of delayed puberty
Genetic analysis can confirm or challenge initial clinical diagnoses, helping doctors refine treatment for adolescents with delayed puberty, report researchers.
Case study: Growth disorder
A 14-year-old boy is referred by his doctor with concerns about his growth.
Bodyweight link to androgen production in prepubertal children confirmed
Measures of obesity are significantly associated with increased androgen production in children, even in the absence of physical signs of puberty, researchers report.
Knowledge gaps make teens with endocrine disorders unready for transition to adult clinic
Researchers find that teenagers with endocrine disorders often have gaps in their knowledge of their condition and how to manage it, making them poorly prepared for transition to adult clinic.
MRI screening ‘most efficient approach’ for CNS lesions in girls with central precocious puberty
Routine use of magnetic resonance imaging for girls with central precocious puberty is the best way to identify occult central nervous system lesions, say Turkish researchers.
Severity of MKRN3 mutation may influence CPP phenotype
Familial central precocious puberty caused by mutations in the makorin RING finger protein 3 gene is phenotypically similar to idiopathic forms, although it can vary with the severity of the mutation, a study shows.
Rates of CPP and normal variant puberty on the rise
The incidences of central precocious puberty and normal variant puberty have risen over the past 20 years, in line with overall population trends for earlier puberty in both girls and boys, say researchers.
The safety profile of growth hormone
Following the publication of the long-term mortality findings of the SAGhE consortium, we discuss the safety profile of growth hormone with consortium member Stefano Cianfarani.
Ovarian failure common, usually during childhood, in girls with APECED
Primary ovarian insufficiency affects the majority of girls with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy, in most cases occurring before they have attained their final adult height, show data from a national cohort.
MKRN3 gene deletion can cause central precocious puberty without PWS
Whole-gene deletion of MKRN3 can cause central precocious puberty without any features of Prader–Willi syndrome, researchers report.