The incidences of central precocious puberty and normal variant puberty have risen over the past 20 years, in line with overall population trends for earlier puberty in both girls and boys, say researchers.
Following the publication of the long-term mortality findings of the SAGhE consortium, we discuss the safety profile of growth hormone with consortium member Stefano Cianfarani.
Primary ovarian insufficiency affects the majority of girls with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy, in most cases occurring before they have attained their final adult height, show data from a national cohort.
Whole-gene deletion of MKRN3 can cause central precocious puberty without any features of Prader–Willi syndrome, researchers report.
Researchers confirm that pubertal timing in girls is most strongly influenced by that of their mothers, whereas for boys their fathers have the stronger influence.
Levels of dehydroepiandrosterone sulfate at the age of 7 years may determine how soon healthy girls progress to thelarche, pubarche and menarche, say researchers.
Research suggests that a single challenge with the neuropeptide kisspeptin can distinguish between children with pubertal delay who will or will not require long-term gonadotropin-releasing hormone therapy.
Pubertal boys with true gynaecomastia have a significantly higher oestradiol-to-testosterone ratio than those with pseudogynaecomastia or healthy controls, observational study data show.
Factors including age at diagnosis and the specific disease influence the likelihood of children with chronic endocrine conditions being lost to follow-up, show French study findings.
Dr Sogol Mostoufi focuses on the treatment-related endocrine side effects commonly experienced by childhood cancer survivors, and the need for screening, life-long follow-up and treatment in this high-risk population.