The randomised Ellipse trial has demonstrated significant blood glucose reductions with the glucagon-like peptide-1 receptor agonist liraglutide in children and adolescents with type 2 diabetes already taking metformin.
Children who start to gain weight in their preschool years are at the highest risk of being obese in adolescence, shows a study in The New England Journal of Medicine.
Impaired glucose tolerance in obese youths frequently reverts to normal, although the chances of this happening are strongly influenced by ethnicity, researchers report in The Lancet Child & Adolescent Health.
The Restoring Insulin Secretion Pediatric Medication Study investigators have found that increased insulin resistance and hyperresponsive beta cells may explain the rapid progression of type 2 diabetes in children.
Obese children with reduced peak stimulated growth hormone are likely to have hyperuricaemia, along with markers of increased cardiovascular risk, research shows.
Surgical treatment of severely obese adolescents with type 2 diabetes is associated with better glycaemic control and a greater reduction in BMI than medical management, US researchers report.
Researchers suggest that obesity could be a factor triggering some girls with premature thelarche to develop precocious or rapidly progressive puberty.
Session attendance was only moderate and self-monitoring very poor in youths with type 2 diabetes who participated in the TODAY lifestyle programme, an analysis shows.
A randomised controlled trial shows some benefit of metformin treatment in prepubertal children with obesity, but not in pubertal participants.
Cognitive behavioural therapy may be a more effective intervention than non-directive, supportive counselling for adolescents with type 1 diabetes who struggle with glycaemic control, a randomised control trial shows.