rhGH treatment has positive growth, body composition effects in Kabuki Syndrome
Recombinant human growth hormone appears to have a positive effect on growth in children with Kabuki Syndrome, shows an open-label study.
IGF-I reference curves show healthy infant growth characteristics
A cohort study of healthy infants has characterised the relationships between circulating levels of insulin-like growth factor (IGF)-I and IGF binding protein (IGFBP)-3 and changes in body length and weight in the first year of life.
Macimorelin shows promise for GHD diagnosis in children
A phase 2 study of macimorelin in children with suspected growth hormone deficiency shows similar results to those established in adults.
Type 1 diabetes risk alleles linked to late-infancy growth
The human leukocyte antigen polymorphisms that increase the risk of type 1 diabetes are linked to growth and insulin-like growth factor-I levels during infancy, say researchers.
Long-acting growth hormone prodrug ‘superior’ to daily somatropin
The heiGHt Trial investigators report that once-weekly treatment with lonapegsomatropin offers noninferior and indeed superior annualised height velocity to that achieved with daily somatropin for children with growth hormone deficiency.
Growth hormone insensitivity encompasses wide range of clinical entities
Researchers have found a large variety of genetic diagnoses in children with short stature investigated for suspected growth hormone insensitivity.
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Scoliosis risk in PWS independent of growth hormone treatment
A long-term follow-up study of children with Prader-Willi syndrome has found no evidence to indicate that growth hormone therapy affects the risk or severity of scoliosis in this population.
Knowledge gaps make teens with endocrine disorders unready for transition to adult clinic
Researchers find that teenagers with endocrine disorders often have gaps in their knowledge of their condition and how to manage it, making them poorly prepared for transition to adult clinic.
Polygenic risk score rivals mid-parental height for predicting adult short stature
A polygenic risk score for height can predict a child’s adult height with similar accuracy to their mid-parental height, say researchers.