Growth hormone insensitivity encompasses wide range of clinical entities
Researchers have found a large variety of genetic diagnoses in children with short stature investigated for suspected growth hormone insensitivity.
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Scoliosis risk in PWS independent of growth hormone treatment
A long-term follow-up study of children with Prader-Willi syndrome has found no evidence to indicate that growth hormone therapy affects the risk or severity of scoliosis in this population.
Knowledge gaps make teens with endocrine disorders unready for transition to adult clinic
Researchers find that teenagers with endocrine disorders often have gaps in their knowledge of their condition and how to manage it, making them poorly prepared for transition to adult clinic.
Polygenic risk score rivals mid-parental height for predicting adult short stature
A polygenic risk score for height can predict a child’s adult height with similar accuracy to their mid-parental height, say researchers.
Endocrinopathy risk highlighted among childhood brain tumour survivors
Around 70% of children who survive a brain tumour develop at least one form of endocrine dysfunction, suggests a long-term study of patients attending a hospital in Portugal.
BMI link to earlier puberty onset in boys confirmed
Longitudinal study findings support a relationship between body mass index and the timing of puberty in boys, with a link found between obesity and precocious gonadarche.
Collagenopathy may underlie some familial short stature cases without clear dysplasia
Collagenopathies could account for around one in 10 cases of familial short stature even when there are no obvious signs of dysplasia, say researchers.
Case study: Prader-Willi syndrome
A 6 years and 5-month-old girl with Prader-Willi Syndrome (PWS) attends endocrine clinic with her mother. She was first seen by the endocrine team at 18 months old and the referral was made by a geneticist. Mum reports she has been obsessive and extremely challenging with her behaviour around food, and she is concerned about her child’s weight.
GH therapy can bring Noonan syndrome children’s height within population norms
A study of children with Noonan syndrome treated in clinical practice shows a good response to growth hormone treatment, with the majority achieving a height within population norms.