Whole-gene deletion of MKRN3 can cause central precocious puberty without any features of Prader–Willi syndrome, researchers report.
An extensive multinational study of patients with disordered thyroid hormone transport due to MCT8 deficiency has identified key characteristics that could help early diagnosis and the treatment of underlying risk factors associated with a poor outcome in affected patients.
Severe growth hormone deficiency can be detected with high accuracy using newborn screening cards, suggest researchers who recommend a diagnostic GH cutoff of less than 7 µg/L.
Researchers confirm that pubertal timing in girls is most strongly influenced by that of their mothers, whereas for boys their fathers have the stronger influence.
Levels of dehydroepiandrosterone sulfate at the age of 7 years may determine how soon healthy girls progress to thelarche, pubarche and menarche, say researchers.
A meta-analysis confirms growth and body composition benefits for children with Prader–Willi syndrome given recombinant human growth hormone.
A major analysis covering three continents suggests that diabetic ketoacidosis remains unacceptably common among children newly identified with type 1 diabetes and shows few signs of improving.
Adding liraglutide 3.0 mg to lifestyle therapy increases weight loss in obese adolescents, show the findings of a placebo-controlled phase 3 trial.
Research suggests that a single challenge with the neuropeptide kisspeptin can distinguish between children with pubertal delay who will or will not require long-term gonadotropin-releasing hormone therapy.
Children with idiopathic growth hormone deficiency should be retested at mid-puberty, say researchers who found a substantial proportion no longer required growth hormone treatment.