Weekly somatrogon noninferior to daily somatropin in paediatric GHD
Weekly injections of somatrogon result in similar height gains to daily somatropin treatment in children with growth hormone deficiency, show results of a 12-month phase 3 trial.
Switch from daily to weekly rhGH feasible and popular for children with GHD
Children with growth hormone deficiency maintain their growth trajectories if they switch from a daily recombinant human growth hormone to weekly lonapegsomatropin, and the vast majority prefer the less frequent injections, show the results of the fliGHt trial.
Weight gain in infancy linked to increased mid-childhood adrenal androgen levels
Children’s weight trajectories between birth and 4 years of age are associated with their dehydroepiandrosterone sulphate levels at age 7 years, study findings show.
Steroid hormone profiles flag non-CAH primary adrenal insufficiency
Steroid hormone profiles can identify the majority of children with non-congenital adrenal hyperplasia primary adrenal insufficiency, say researchers.
Transient congenital hypothyroidism predictors identified
Over a third of children diagnosed with congenital hypothyroidism have discontinued treatment within 10 years of diagnosis, say French researchers who have identified predictive markers for a transient prognosis.
Levo-thyroxine dose may need more initial adjustment with solution than pills in congenital hypothyroidism
Children using an oral solution of levo-thyroxine for treatment of congenital hypothyroidism may require closer monitoring during the first few months than those using tablet formulations, say researchers.
Rare GNAS mutations may underpin severe obesity even in absence of pseudohypoparathyroidism
Researchers have identified pathogenic mutations in the gene encoding the stimulatory G-protein alpha subunit protein in children with severe obesity but few or no clinical signs of pseudohypoparathyroidism.
Negative pituitary MRI influences remission, not recurrence of paediatric Cushing’s disease
Children with Cushing’s disease who have a negative magnetic resonance imaging pituitary scan are less likely to achieve remission after surgery than those with a confirmed tumour, say researchers.
Harmonised BMD surveillance guidance for young cancer survivors released
An international expert group has published recommendations for the monitoring of bone mineral density in child, adolescent and young adult survivors of cancer.
Type 1 diabetes risk alleles linked to late-infancy growth
The human leukocyte antigen polymorphisms that increase the risk of type 1 diabetes are linked to growth and insulin-like growth factor-I levels during infancy, say researchers.