Weekly somatrogon noninferior to daily somatropin in paediatric GHD
Weekly injections of somatrogon result in similar height gains to daily somatropin treatment in children with growth hormone deficiency, show results of a 12-month phase 3 trial.
Increased peak GH response with oral GH secretagogue receptor agonist in children with GHD
An oral growth hormone secretagogue receptor agonist produces larger GH responses than standard stimulation tests in children with growth hormone deficiency, study findings suggest.
rhGH therapy boosts adult height among children with SHOX haploinsufficiency
A study of Brazilian children with isolated SHOX haploinsufficency who were followed up until adult height has demonstrated a long-term benefit of recombinant human growth hormone therapy with or without puberty modulator treatment.
Switch from daily to weekly rhGH feasible and popular for children with GHD
Children with growth hormone deficiency maintain their growth trajectories if they switch from a daily recombinant human growth hormone to weekly lonapegsomatropin, and the vast majority prefer the less frequent injections, show the results of the fliGHt trial.
Silver-Russell syndrome patients derive lasting height and BMI benefits from rhGH treatment
Treatment with recombinant human growth hormone results in an increased final adult height in children with molecularly confirmed Silver–Russell syndrome, as well as an improved BMI that persists after treatment cessation, say researchers.
Growth hormone benefit in Noonan syndrome demonstrated regardless of PTPN11 mutation status
The benefit of initiating recombinant human growth hormone before puberty in patients with Noonan syndrome occurs regardless of whether the children carry a PTPN11 mutation, suggests research published in Endocrine Connections.
Weight gain in infancy linked to increased mid-childhood adrenal androgen levels
Children’s weight trajectories between birth and 4 years of age are associated with their dehydroepiandrosterone sulphate levels at age 7 years, study findings show.
Early-life growth linked to pubertal timing
A large study shows that growth in the first 5 years of life is associated with age at pubertal onset.
Inflammatory biomarkers elevated in paediatric Cushing’s syndrome
Blood-cell markers of inflammation are elevated in children with Cushing’s syndrome and may offer useful diagnostic information, say researchers.
First-line next-generation sequencing could simplify 46,XY DSD diagnosis
Researchers recommend next-generation sequencing for the first-line diagnosis of patients with 46,XY differences of sex development.