Children with monogenic obesity linked to mutations in the leptin-melanocortin pathway have lower cardiac muscle mass than other obese children, as well as greater tissue storage of sodium, research suggests.
Research from New Zealand shows that the rate of false-positive neonatal screening tests for congenital adrenal hyperplasia can be reduced without a loss in sensitivity by assessing additional steroid markers adjusted for birthweight or corrected gestational age.
Researchers have found a large variety of genetic diagnoses in children with short stature investigated for suspected growth hormone insensitivity.
A long-term follow-up study of children with Prader-Willi syndrome has found no evidence to indicate that growth hormone therapy affects the risk or severity of scoliosis in this population.
Measures of obesity are significantly associated with increased androgen production in children, even in the absence of physical signs of puberty, researchers report.
Many children with congenital adrenal hyperplasia may be receiving excessively high hydrocortisone doses, especially during the earliest months of life, a study suggests.
Researchers find that teenagers with endocrine disorders often have gaps in their knowledge of their condition and how to manage it, making them poorly prepared for transition to adult clinic.
A polygenic risk score for height can predict a child’s adult height with similar accuracy to their mid-parental height, say researchers.
Routine use of magnetic resonance imaging for girls with central precocious puberty is the best way to identify occult central nervous system lesions, say Turkish researchers.
Around 70% of children who survive a brain tumour develop at least one form of endocrine dysfunction, suggests a long-term study of patients attending a hospital in Portugal.