The incidences of central precocious puberty and normal variant puberty have risen over the past 20 years, in line with overall population trends for earlier puberty in both girls and boys, say researchers.
Researchers have identified probable type 1 diabetes in children of an age more commonly associated with diagnosis of monogenic diabetes, raising the possibility that polygenic disease processes can begin in utero.
A single measurement of plasma levels of a fragment of type X collagen may give an instant picture of how fast a child is growing, say researchers.
The diagnosis of central congenital hypothyroidism with or without multiple pituitary hormone deficiencies is frequently missed in children, even among those admitted to hospital, say Dutch researchers.
A randomised trial of children receiving treatment for thyrotoxicosis shows no difference in biochemical stability between block-and-replace and dose-titration strategies.
Rare copy number variants have been identified in a study of children who have growth hormone insensitivity or insulin-like growth factor-1 insensitivity, shedding light on the genetic basis of their conditions.
Hydrocortisone granules provide a straightforward and accurate means of treating infants and young children with congenital adrenal hyperplasia, with the largest issue being weaning them off sweetened pharmacy-compounded powder, research shows.
The C-type natriuretic peptide analogue vosoritide significantly increases the growth rate of children with achondroplasia, indicate the results of a randomised, double-blind phase 3 study published in The Lancet.
Children who receive total body irradiation or craniospinal radiation for cancer may have a reduced response to growth hormone therapy if they later require it, say researchers.
UK researchers have identified an increase in the number of childhood cases of new-onset type 1 diabetes during the COVID-19 pandemic, raising the possibility of a link with SARS-CoV-2 infection.