The human leukocyte antigen polymorphisms that increase the risk of type 1 diabetes are linked to growth and insulin-like growth factor-I levels during infancy, say researchers.
The heiGHt Trial investigators report that once-weekly treatment with lonapegsomatropin offers noninferior and indeed superior annualised height velocity to that achieved with daily somatropin for children with growth hormone deficiency.
Overweight and obese boys have reduced testosterone levels and shorter penises during puberty than their normal-weight counterparts, study findings demonstrate in The Journal of Clinical Endocrinology & Metabolism.
Findings from the PATRO Children study support the use of a biosimilar formulation of recombinant human growth hormone in children with Turner’s syndrome.
Children with monogenic obesity linked to mutations in the leptin-melanocortin pathway have lower cardiac muscle mass than other obese children, as well as greater tissue storage of sodium, research suggests.
Research from New Zealand shows that the rate of false-positive neonatal screening tests for congenital adrenal hyperplasia can be reduced without a loss in sensitivity by assessing additional steroid markers adjusted for birthweight or corrected gestational age.
Researchers have found a large variety of genetic diagnoses in children with short stature investigated for suspected growth hormone insensitivity.
A long-term follow-up study of children with Prader-Willi syndrome has found no evidence to indicate that growth hormone therapy affects the risk or severity of scoliosis in this population.
Measures of obesity are significantly associated with increased androgen production in children, even in the absence of physical signs of puberty, researchers report.
Many children with congenital adrenal hyperplasia may be receiving excessively high hydrocortisone doses, especially during the earliest months of life, a study suggests.