Health-related quality of life in women with Turner syndrome bears little or no relation to their height and whether they received growth hormone treatment as a child, say researchers.
Data from clinical practice support the option of adding gonadotrophin-releasing hormone analogue to growth hormone therapy in some clinical situations to extend the treatment window and optimise final height in children with idiopathic short stature.
Delayed puberty is common in the developed world, affecting over 2% of adolescents, and is associated with adverse health outcomes including short stature, reduced bone mineral density and compromised psychosocial health.
medwireNews goes behind the headlines, talking to researchers and independent experts about how the latest findings will impact clinicians caring for children with endocrine disorders.
A study of patients with mutations or terminal deletions in the insulin-like growth factor 1 receptor gene shows that the majority are small for gestational age, short and microcephalic, with an elevated serum IGF-1 level.
Research shows that growth hormone deficiency and central precocious puberty can occur in children several years after traumatic brain injury (TBI), even among those with normal pituitary function 1 year after the event.
Basal adrenal androgen levels can help identify girls with non-classical congenital adrenal hyperplasia who present as central precocious puberty, but adrenocorticotrophic hormone stimulation may be needed for a firm diagnosis, say researchers.
Children with short stature show marked improvements in their emotional and social quality of life during their first year of treatment with growth hormone, study findings suggest.
Burosumab treatment improves rickets and prevents decline in growth in young children with X-linked hypophosphataemia, show the findings of an open-label phase II study.
A probable underlying genetic cause may be found for the majority of children with severe familial short stature, with mutations in growth plate genes accounting for most of these, research shows.