Weekly somatrogon noninferior to daily somatropin in paediatric GHD
Weekly injections of somatrogon result in similar height gains to daily somatropin treatment in children with growth hormone deficiency, show results of a 12-month phase 3 trial.
Increased peak GH response with oral GH secretagogue receptor agonist in children with GHD
An oral growth hormone secretagogue receptor agonist produces larger GH responses than standard stimulation tests in children with growth hormone deficiency, study findings suggest.
rhGH therapy boosts adult height among children with SHOX haploinsufficiency
A study of Brazilian children with isolated SHOX haploinsufficency who were followed up until adult height has demonstrated a long-term benefit of recombinant human growth hormone therapy with or without puberty modulator treatment.
Case study: Management of Silver–Russell Syndrome
A 4-year-old girl is referred to the local paediatric endocrine unit with signs of pubertal development.
Switch from daily to weekly rhGH feasible and popular for children with GHD
Children with growth hormone deficiency maintain their growth trajectories if they switch from a daily recombinant human growth hormone to weekly lonapegsomatropin, and the vast majority prefer the less frequent injections, show the results of the fliGHt trial.
Silver-Russell syndrome patients derive lasting height and BMI benefits from rhGH treatment
Treatment with recombinant human growth hormone results in an increased final adult height in children with molecularly confirmed Silver–Russell syndrome, as well as an improved BMI that persists after treatment cessation, say researchers.
Growth hormone benefit in Noonan syndrome demonstrated regardless of PTPN11 mutation status
The benefit of initiating recombinant human growth hormone before puberty in patients with Noonan syndrome occurs regardless of whether the children carry a PTPN11 mutation, suggests research published in Endocrine Connections.
Digital developments and precision medicine in paediatric growth disorder management
Recorded: Thursday 5 November, 2020
Professor Savage was joined by growth disorder and digital health specialists to address resistant factors to the adoption of technology.
MKRN3 gene deletion can cause central precocious puberty without PWS
Whole-gene deletion of MKRN3 can cause central precocious puberty without any features of Prader–Willi syndrome, researchers report.
Awareness of MCT8 deficiency causing abnormal thyroid hormone transport may help early diagnosis
An extensive multinational study of patients with disordered thyroid hormone transport due to MCT8 deficiency has identified key characteristics that could help early diagnosis and the treatment of underlying risk factors associated with a poor outcome in affected patients.