Liraglutide enhances weight loss in obese adolescents
Adding liraglutide 3.0 mg to lifestyle therapy increases weight loss in obese adolescents, show the findings of a placebo-controlled phase 3 trial.
Kisspeptin-stimulation test response predicts delayed puberty outcome
Research suggests that a single challenge with the neuropeptide kisspeptin can distinguish between children with pubertal delay who will or will not require long-term gonadotropin-releasing hormone therapy.
Mid-puberty retesting advised to identify resolved GHD
Children with idiopathic growth hormone deficiency should be retested at mid-puberty, say researchers who found a substantial proportion no longer required growth hormone treatment.
Glucose tolerance test may be best for type 2 diabetes diagnosis in youth
An oral glucose tolerance test may identify youths with a more adverse cardiometabolic profile than a fasting plasma glucose test does, say researchers.
Polygenic risk score may predict familial short stature in Chinese children
Researchers have identified 10 novel single nucleotide polymorphisms that may help to predict the risk for familial short stature in Han Chinese children.
Small SOX3 duplications can cause hypopituitarism and neural tube defects
A case series illustrates the highly variable phenotypes of patients with congenital hypopituitarism caused by SOX3 duplication, and strengthens the association with neural tube defects.
Four daily hydrocortisone doses best mimic physiological cortisol profile for CAH patients
Giving hydrocortisone four times daily at a time-varying dose may be the best approach for children with congenital adrenal hyperplasia, say the authors of a pharmaco (P)-kinetic and P-dynamic modelling study.
GH therapy ‘promising’ for familial short stature children with an NPR2 mutation
Children with familial short stature (FSS) who have mutations in their C-type natriuretic peptide receptor (NPR2) gene may respond well to growth hormone (GH) therapy, preliminary study findings indicate
High oestradiol-to-testosterone ratio characterises true gynaecomastia
Pubertal boys with true gynaecomastia have a significantly higher oestradiol-to-testosterone ratio than those with pseudogynaecomastia or healthy controls, observational study data show.
Factors predicting loss to follow-up identified for children with chronic endocrine conditions
Factors including age at diagnosis and the specific disease influence the likelihood of children with chronic endocrine conditions being lost to follow-up, show French study findings.