Growth Disorders

01 March 2017
medwireNews: The long-acting TransCon growth hormone (GH) has shown comparable efficacy and safety to standard daily somatropin in children with GH deficiency (GHD) in a phase II trial. TransCon GH consists of GH transiently bound to methoxypolyethylene glycol by a proprietary linker, allowing the active drug to be released over the course of... Read More
30 January 2017
medwireNews: Research shows that insulin sensitivity improves during the first 5 years after stopping long-term recombinant human growth hormone (rhGH), despite an increase in fat mass, in young adults born small for gestational age (SGA). In a commentary accompanying the study in The Lancet Diabetes & Endocrinology, Nicholas... Read More
23 December 2016
medwireNews: Twenty-five years of data from the Pfizer International Growth Study (KIGS) confirm that more boys than girls undergo treatment with growth hormone (GH). The team found that boys accounted for 58% of the 83,803 children from Europe, the USA and Japan recorded in the KIGS database. This male predominance was seen for all... Read More
30 November 2016
medwireNews: A study details the clinical characteristics of patients who have autosomal dominant short stature caused by heterozygous mutations in the aggrecan gene (ACAN). Patients with the condition frequently have advanced bone age, and joint and back problems are common, the researchers report in The Journal of Clinical... Read More
28 October 2016
medwireNews: French researchers have characterised the associations between gender, genotype and phenotype in a cohort of patients with mutations affecting the SHOX (short stature homeobox gene) region. “Our analysis confirms the higher penetrance and the different expression of SHOX rearrangements in females compared to... Read More
30 September 2016
medwireNews: A candidate gene approach does not identify a panel of genes that can predict the growth response to recombinant human growth hormone (rhGH) better than clinical factors alone, show the findings of the PREDICT validation study. The validation study included 293 patients with growth hormone deficiency (GHD) and 132 with Turner... Read More