Growth Disorders

28 April 2017
medwireNews: Researchers have calculated the optimal times to take blood samples for measuring insulin-like growth factor (IGF)-1 levels in children with growth hormone deficiency (GHD) receiving the long-acting growth hormone MOD-4023. Peak IGF-1 is best determined on day 2 after MOD-4023 dosing, but mean IGF-1 is better determined on day 4,... Read More
31 March 2017
medwireNews: Analysis of the KIGS database confirms the beneficial effects of recombinant human growth hormone (rhGH) on height and weight in children with Prader–Willi syndrome (PWS). Nienke Bakker (Dutch Growth Research Foundation, Rotterdam) and colleagues studied two groups of PWS patients: 522 who received at least 3 years of rhGH... Read More
01 March 2017
medwireNews: The long-acting TransCon growth hormone (GH) has shown comparable efficacy and safety to standard daily somatropin in children with GH deficiency (GHD) in a phase II trial. TransCon GH consists of GH transiently bound to methoxypolyethylene glycol by a proprietary linker, allowing the active drug to be released over the course of... Read More
30 January 2017
medwireNews: Research shows that insulin sensitivity improves during the first 5 years after stopping long-term recombinant human growth hormone (rhGH), despite an increase in fat mass, in young adults born small for gestational age (SGA). In a commentary accompanying the study in The Lancet Diabetes & Endocrinology, Nicholas... Read More
23 December 2016
medwireNews: Twenty-five years of data from the Pfizer International Growth Study (KIGS) confirm that more boys than girls undergo treatment with growth hormone (GH). The team found that boys accounted for 58% of the 83,803 children from Europe, the USA and Japan recorded in the KIGS database. This male predominance was seen for all... Read More
30 November 2016
medwireNews: A study details the clinical characteristics of patients who have autosomal dominant short stature caused by heterozygous mutations in the aggrecan gene (ACAN). Patients with the condition frequently have advanced bone age, and joint and back problems are common, the researchers report in The Journal of Clinical... Read More