Growth Disorders

01 March 2018
medwireNews: Cyproheptadine hydrochloride may have beneficial effects on growth that are unrelated to its influence on appetite in children with growth hormone (GH) insensitivity syndrome, report researchers. Maryam Razzaghy-Azar (Iran University of Medical Sciences, Tehran) and co-workers tested the medication in 15 such patients, following... Read More
01 February 2018
medwireNews: A study reports the characteristics of a series of patients with heterozygous mutations in the gene encoding aggrecan (ACAN). Fourteen of the 16 reported cases had short stature, with a median height standard deviation score (SDS) of –2.9, and mild skeletal dysplasia, and the other two cases had spondyloepiphyseal... Read More
01 February 2018
medwireNews: The benefits of prompt growth hormone (GH) treatment are apparent even in patients diagnosed as deficient at a very young age, a study suggests. The researchers also found that treatment response differed according to whether the patients had multiple pituitary hormone deficiency (MPHD) or isolated GH deficiency (IGHD). And they... Read More
02 January 2018
medwireNews: Factors including injection exhaustion create barriers to adherence in patients taking growth hormone (GH), but differ between children and adolescents, study findings suggest. When adherence was assessed with the 8-item Morisky Medication Adherence Scale (MMAS), Mania Radfar (Tehran University of Medical Sciences, Iran) and co-... Read More
30 November 2017
medwireNews: Heterozygous mutations in the Indian hedgehog gene (IHH) are a potential cause of idiopathic short stature (ISS), say researchers who report that children with these mutations appear to respond well to treatment with recombinant human growth hormone (rhGH). The researchers say their work has “extended the known phenotype... Read More
30 October 2017
medwireNews: Factors including age at initiation of growth hormone (GH) therapy and severity of inflammation during treatment determine whether children with juvenile idiopathic arthritis (JIA) will achieve a favourable growth outcome, study results show. The researchers stress that “clinical monitoring of growth remains crucial”, because the... Read More